Clinial Tools

AML-G1-G8

• Introduction

  Predictiton of the GEP-defined AML subtypes.

  G1: PML::RARA

  G2: CBFB::MYH11

  G3: RUNX1::RUNXT1

  G4: biCEBPA/-like

  G5: myelodysplasia-related/-like

  G6: HOX-committed

  G7: HOX-primitive

  G8: HOX-mixed## AML-G1-G6

• Introduction

  Bagging models to predict the GEP-defined AML subtypes.

  G1: PML-RARA

  G2: CBFB-MYH11

  G3: RUNX1-RUNXT1

  G4: Bialleic CEBPA

  G5: ...

  G6: NPM1/KMT2A/NUP98...

• Extra parameters

  Data normalization method: deseq2 vst or log2 (tpm + 1)

  Model: xgboost or autogluon

• Other notes

  Gene symbols of models are based on the hg38 GENCODE v34 gene annotation file

  'label' row is only used to check results for users and will be automatically removed in the program